Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2".
نویسندگان
چکیده
Jiao and Liu (Research Articles, 16 October 2015, aac4383) reported the crystal structure of the protein complex polycomb repressive complex 2 from Chaetomium thermophilum This landmark structure has brought invaluable insights into the activation mechanism of this essential methyltransferase. However, the analysis of the x-ray data discussed below suggests that the description of oncogenic H3K27M peptide binding to the active site is incorrect.
منابع مشابه
Response to Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2".
Zhang et al suggested that in the crystal structure of a polycomb repressive complex 2 from Chaetomium thermophilum (ctPRC2), a flexible linker region, but not the H3K27M cancer mutant peptide, better fits the electron density. Based on our new data, we agree with this alternative interpretation and provide the crystal structure of ctPRC2 bound to a bona fide H3K27M sequence.
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ورودعنوان ژورنال:
- Science
دوره 354 6319 شماره
صفحات -
تاریخ انتشار 2015